Abstract: The application of colloidal drug delivery system in biomedical field has changed the definitions of diagnosis and treatment. Colloidal drug carriers such as liposomes, ethosomes, lipospheres, transferosomes, nanoparticles, microspheres etc. are used to improve the therapeutic index of both existing and new drug molecules by modifying their distribution and thus increase their efficacy and reduce their toxicity. Such delivery systems are widely used in gene delivery, targeting to tumor, targeting to brain, oral formulations, in stability and permeability problem of drug also. In the series of these vesicular systems, colloidosomes is the advanced tool in drug delivery. Colloidosomes are the hollow shell microcapsules consisting of coagulated or fused particles at interface of emulsion droplets. Colloidosomes have exciting potential applications in controlled release of drugs, proteins, vitamins as well as in cosmetics and food supplements. Colloidosomes have a great encapsulation efficacy with a wide control over size, permeability, mechanical strength and compatibility. This review focuses on the types, properties fabrication techniques, characterization and stability of colloidosomes.