Abstract: Aim was to investigate the modifying effects of ethanolic extract of Clerodendron inerme leaves on membrane integrity by measuring the levels of plasma and erythrocyte membrane glycoconjugates and red blood cell osmotic fragility during 7,12-dimethylbenz(a)anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice. The skin squamous cell carcinoma was induced in the shaved back of mice, by painting with DMBA (25 μg/0.1 mL acetone) twice weekly for 8 weeks. We have observed 100% tumor formation in the fifteenth week of experimental period. The status of glycoconjugates in plasma and erythrocyte membrane and red blood cell osmotic fragility was assayed by using specific colorimetric methods. The levels of glycoconjugates were increased in plasma whereas decreased in erythrocyte membrane of DMBA treated animals as compared to control animals. Red blood cells from tumor bearing animals were more fragile than those from control animals. Oral administration of ethanolic leaf extract of Clerodendron inerme (CILEE) 300 mg kg-1 b.wt. significantly prevented the tumor formation as well as restored the status of glycoconjugates and red blood cell osmotic fragility in DMBA treated animals. The present study thus demonstrates the protective effect of CILEE on red blood cell membrane integrity during DMBA induced mouse skin carcinogenesis.