Abstract: Serodiagnosis of Haemonchus contortus by ELISA using adult crude somatic and excretory-secretory antigens of Haemonchus contortus was tested in the present study. The diagnostic sensitivity of ELISA using excretory secretory antigens was 87.5% which was significantly higher compared to crude somatic antigen 72.22%. Mean ELISA absorbance value of excretory-secretory antigens was significantly higher corresponding to crude somatic antigens. Excretory secretory antigens showed 92.02% specificity compared to 76.81% of crude somatic antigens (p<0.05). The results revealed that excretory secretory antigens are very sensitive and may be useful as a supplementary method for diagnosis of Haemonchosis in ruminants.