Abstract: Background and Objective: Cobb 500 is one of the world’s most popular broiler breed. The present study was undertaken to evaluate the performance of this breed under small scale at Assosa town of Ethiopia and to promote the breed for wider use. Materials and Methods: To do so, nine urban farmers were selected and provided with appropriate training regarding broiler management. Farmers made poultry houses ready prior to arrival of chickens and each farmer received 100 day-old chicks with recommended type and level commercial feeds. Appropriate vaccinations were given and standard bio-security measures were employed in all farms throughout the study period. Daily feed intake, weekly body weight, mortality and its cause, variable costs and revenues were recorded at each farm. Carcass processing was done at the end of 7th and 8th weeks of study period. Forty randomly selected birds were used to evaluate the carcass characteristics from all farms and both male and female chickens were considered. Data analysis was done by using SPSS (Version 20) software. Descriptive and one way ANOVA techniques using General Linear Model procedures were used for data analysis. Results: Feed intake of Cobb 500 commercial broiler for this study under Assosa condition was comparable to target feed intake of the breed, but feed conversion ratio was slightly higher than the target performance of the breed. The mean body weights at the end of 7th and 8th weeks were 3.1 and 3.8 kg, respectively. Carcass characteristics were affected by age and sex of chickens. The overall mortality rate recorded in this study was 7.8%. Among the dead chickens, 54.9% of them died in the first week indicating the importance of the first week in broiler chicks to implement proper management practices under small scale production. Conclusion: It is concluded that Cobb 500 commercial broiler showed good growth performance and the partial budget analysis indicated that growing broilers at Assosa is profitable given that appropriate management was followed as per the breed’s management guideline.