Abstract: Background and Objective: The response of each sweet potato variety that was planted during the rainy season was significantly different. Some varieties showed high response to the environment with the components of vegetative growth especially on stems and leaves as shown from the observation. The purpose of this study was to determine the response of 10 varieties of sweet potatoes that were planted during the rainy season through the analysis of their growth and yield. It was conducted to know which varieties were able to adapt well and produce a high yield in the peculiar environment. Materials and Methods: This study was conducted using a Randomized Block Design with three replications and comprised ten varieties of sweet potatoes viz: Papua, Sollosa, Jago, Kidal, Antin-1, Sari, Sawentar, Beta-2, Antin-2, Antin-3 and Beta-1. The data were analyzed by one-way analysis of variance (ANOVA) at 5% level and for a significant effect followed Fisher’s Least Significant Differences (LSD) test at the 0.05 probability. Result: The results showed that the optimum Leaf Area Index (LAI) of sweet potatoes were found when the sweet potatoes entered the age of 3 MAP. The LAI of Sawentar variety showed the value of 7.23, while varieties Sari and Beta-2 were in the optimum limit of LAI response. This is proved by the growth of vegetative organs which reached the highest when entering the age of 3 months after planting. To inhibit the crop growth rate of vegetative organs, shoots pruning at age of 3 MAP should be done, therefore the assimilates can be translocated to the tubers as generative organs. This study found some varieties having high production such as Sari and Papua Sollosa varieties. Conclusion: The yield of the sweet potato varieties on the experiment showed a negative correlation to the leaf area and LAI, in which to achieve high productivity, low LAI value is required. Sari variety is recommended to be grown at the dry land during rainy season, by using this treatment sweet potato yield could produce 44.76 t ha–1.