Abstract: This study was carried out to determine the effects of four Plant Growth Regulators (PGRs) (Atonik, GA3, Cytozyme Crop Extra and Megahix), two nutrient complexes (Biomaster and Kinetic) and a see weed extract (Maxicrop) on pod-shattering rate and yield loss of both main and double-cropped soybean grown in a prolonged hot and dry condition in 2002 and 2003. The soybean cultivar was A 3935. The experimental design was randomized complete block with four replications. Application of PGRs remarkably lowered the shattering rates and seed yield losses only for main-cropped soybean. The lowest shattering rates and yield losses were obtained from Atonik and Cytozyme applications until 10 days after R8 growth stage for main-cropped soybean. The positive effects of PGRs on shattering rate and yield losses were decreased with the increasing delay of harvest. The results of the current study showed that seed yield losses of main-cropped soybean could be alleviated by the application of Atonik, Megahix and Cytozyme. However application of PGRs was not suggested for double-cropped soybean if the scope was to reduce yield losses caused by pod shattering.