Abstract: Mianwali is the part of Salt range, which is considered as the field museum of the Pakistan. Medicinal and economically important, naturally occurring species of the Dhibbia Karsal Village were surveyed on the basis of the perception of local people. The local communities are extremely knowledgeable about the local plants but unfortunately this knowledge is going to be lost as a traditional culture is disappearing. Plants of thirty-eight different species belonging to different families of angiosperm having medicinal importance. Due to the salinity of the soil dominating species are perennial. Olea ferruginea Royle and Acacia modesta are two medicinally important characteristic trees of this area. Olea ferruginea due to extensive cutting and grazing has become rare species of the area. Solanum nigrum, S. villosum, S. americanum and S. surattense are common species of the area and exhibit great diversity in morphology. These species use commonly as the painkiller. They are very good source of tropane alkaloids. A trend of change in vegetation from forest to scrub and then to a treeless grassy area was observed. Factors responsible for loss of species diversity are mainly biotic and salinity of the soil.