Abstract: Plant breeders are much concerned about the durability of the resistance gene(s) that they are incorporating into the better performing backgrounds to tolerate biotic stresses. While resistance that is controlled by a single major gene (vertical resistance) is simple to achieve, the one controlled by poly genes (horizontal resistance) is not. There are a number of ways to make the non-durable resistance genes durable. Comprehensively, the exploitation of genes with known durability, the use of quantitative resistance and the use of gene deployment are suggested to be some of them that can lead to the better ways of achieving durability of resistance. There are also various approaches of deploying genes to achieve durability of resistance. Therefore, to realize durability of disease resistance genes in crop plants any one of the approaches that are dealt in this study can be used without compromising their economic feasibility.