Abstract: Ethanolic extracts of 16 Turkish plant species used in folk medicine were investigated for their antimicrobial activities against nine bacterial species (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus vulgaris, Bacillus cereus, Mycobacterium smegmatis, Listeria monocytogenes and Micrococcus luteus) and three yeasts (Candida albicans, Kluyveromyces fragilis and Rhodotorula rubra) using the disc diffusion method. Of the 16 plants tested, ten showed antimicrobial activity. Each plant species has unique against different microorganisms. The most active antimicrobial plant against bacteria and yeasts was Myrtus communis. It is conclude the plants studied may be sources of antimicrobial agents.