Abstract: The research work was conducted to investigate the antifungal activity of hexane, chloroform, ethanol and water extracts of the leaves of Melia azedarach L., Vitex negundo and Broussontia papyrifera and fruit of Datura anoxia were evaluated against Rhizopous niger, Fusarium chlamdosporum, Aspergillus niger, Stemphlium wallr and Hyloflora ramosa using clotrimazole as a reference standard. The antifungal activity was observed for ethanolic and hexane extracts of B. papyrifera. The chloroform extracts of M. azedarach L. was active against F. chlamdosporum (6.6 mm) and the chloroform extract of D. innoxia was inactive against all of the fungi tested. The water extract of D. innoxia showed highest activities against fungi S. wallr (4.95 mm) and minimum activity was observed for V. negundo against S. wallr (3.30 mm). Hexane extracts of B. papyrifera showed the highest antifungal activity against F. chlamdosporum (8.36 mm) and minimum was observed for V. negundo against R. niger (2.85 mm). The antifungal activities for all of the plants extracts were weak and it is not possible to use these plant extracts for the control of fungal diseases.