Abstract: The experiment was laid-down to determine the inter and intra row spacing effect on the growth, seed and oil production of safflower crop. Three row spacing (25, 35, and 45cm) and three plant spacing (15, 22 and 30 cm) where applied to Thori-78 safflower variety. It was observed that crop maturity, plant height, number of branches, number of capitula, seed and oil content varied significantly between inter and intra row spacing as well as their interactions. Safflower planted at the distance of 45 x 30cm row to row and plant to plant recorded significantly maximum seed yield, plant height, oil production, branches and capitula number of the crop. However, closer space between row and plant (25 x 15cm) prolonged maturity days. Thus, it was concluded that safflower crop should be planted at 45 x 30 cm row and plant distance for maximum seed and oil production.