Abstract: Background and Objective: Plantain is an important food for many populations in many countries of the humid tropics. However, its production in traditional farming systems by smallholders is threatened by Black Leaf Streak Disease (BLSD) caused by the ascomycete fungus Mycosphaerella fijiensis Morelet responsible for significant crop losses. Limitations and disadvantages relating to the methods of chemical and genetic control of this disease suggest the efficient use of tolerant hybrids in reasoned combination between other strategies (such as chemical and biological control) that are available to the producer. This study was conducted in order to compare the agronomic performance of plantain varietal crop combinations for sustainable management of BLSD in the very susceptible cultivar "Orishele" under conditions of natural infestation. Methodology: For this purpose, two trials were set up in Azaguie-Ahoua, in Southeastern Côte d’Ivoire, in 2013 and 2014 according to an experimental design of split-plot. Three repetitions each including treatments were assessed. Observations were made mainly on yield parameters in the first cropping cycle. Results: Significant differences were observed between the number of functional leaves at flowering and harvest, the bunch weight, the number of fingers of the bunch, the number of fingers, the weight, the length and width of reference fruits of the second and fourth hands. The best values were obtained with "Orishele" in crop combination with seedlings tolerant to BLSD in the different prototypes. However, no difference was observed between cropping cycles (Planting-flowering-harvest). Conclusion: These results show that plantain cultivation in combination with sensitive and tolerant varieties in almost equal proportions is a good strategy to slow down the spread of BLSD and ensure a better yield at harvest in cultivars sensitive to this disease.