Abstract: Background and Objectives: Salvadora persica L. is specie of halophytes occurs in arid and semi-arid regions of Asia and Africa. The aims of the study was to optimize the physiological state of S. persica and its stability in dry environment Materials and Method: Salvadora persica L., plant had been collected from Rabigh province and been subjected to physiological state evaluation. The evaluation included leaf area, photosynthetic parameters and transpiration rate, trehalose content and catalase activity. The leaf area was 4.71 cm2. Results: The maximum net rates of photosynthesis (A) and transpiration (E) were 53.96 and 6.44 mmol m–2 sec–1, respectively. The photosynthetic parameter of S. persica leaf were, Vapor pressure deficit, stomatal conductance to water vapor, substomatal CO2, water use efficiency and photosynthetic active radiance has been measured. In S. persica L., shoot, the trehalose content was 4.33 μg g–1 dry weight and catalase activity (CAT) was 3.58 mM H2O2 g–1 fresh weight min–1. Chemical ions have been analyzed both in plant shoots and the soil rhizosphere. The remarkable points of these analyses are the presence of high level of Ca2+ in plant shoots and high level of Fe2+ in the soil rhizosphere. Conclusion: This study established that S. persica grew and developed well in this dry area. As well as, it can be used to fix sands, indeeds the fixation represents a point of interest for biologists and economists.