Abstract: Weed management remains a major concern for farmers in developed countries than in developing countries. To produce better, farmers in developing countries seek to keep weeds below the economic threshold. Fertilization as weed management mode did not allow to overcome this challenge because except its effects on crops, fertilization stimulates seed dormancy in the seed stock of previous season and the growth of some weed species. In this regard, nitrogen was one of the responsible macronutrients. Therefore, splitting doses of mineral fertilizers resulted in better growth and development of crops. As for organic amendments, their effectiveness is dependent on the origin, nature and shelf life etc. Furthermore, the combination of fertilizers and herbicides resulted in non-additivity of effects especially herbicide is rapidly degraded in the soil but most herbicides containing the radical urea have made an exception. Physico-chemical properties of soils, application moments and compatibility of active ingredients are determining factors of fertilizer and herbicide efficiency.