Abstract: Nigeria’s economic development remains sluggish, declining in an environment that does not encourage entrepreneurs, who are globally proven as engines of economic growth. Three out of 4 micro, small and medium enterprises die every year in the country. Nine out of 10 prospective entrepreneurs are discouraged from establishing their dream industries. Many state-owned enterprises have been privatized for insolvency. Multinational corporations are leaving the country. This study examines the strategies adopted by some surviving entrepreneurs in Nigeria. Data were gathered from 80 randomly selected entrepreneurs in the Southeast Nigeria, using questionnaire and interviews. Strategies adopted by most of the surviving enterprises include improved staff education/training, substitution of imported with local raw materials, use of locally fabricated machines, direct marketing approach and research and development programme. These strategies are, therefore, recommended, among others, for entrepreneurs to enable them keep afloat in the ailing Nigerian economy.