Abstract: Background and Objective: Stroke is a disease condition caused by the interruption of the blood flow supplying the brain; it is a sudden blockage or rupture of blood veins. This condition causes brain tissue to not be exposed to the blood flow of oxygen and nutrients, with the brain becoming damaged. The aim of this research was to determine the model of risk factors for stroke in South Sulawesi. Materials and Methods: This study use observational analytic research with a case control design, which is a study design that epidemiologists use to study relationship concerning the level of exposure to a variety of disease states or other health problems. A case is a stroke patient and the control is someone who is not a stroke patient. This analysis uses odds ratio logistic regression and the value of α = 0.05. Results: The results of this research show the significant association between stroke with hypertension, Odd Ratio (OR) = 4.06, with 95% CI 3.25-5.0; the association of physical activity with the occurrence of stroke, OR = 1.69, with 95% CI 1.29-2.23 and the association of obesity and stroke, OR = 2.00 with 95% CI 1.64-2.47.There is a relationship between smoking and the incidence of stroke, OR = 1.81 with 95% CI 1.42-2.32; however, for stress, p = 0.619 (p>0.05), which means that stress has no relationship with the incidence of stroke, OR = 1.10 with 95% CI 0.75-1.63. Conclusion: To conclude that stroke might be leaded due to the less physical activity, smoking and stressful lifestyle behaviors that end with hypertension. Hypertension is the risk factor that most influences the incidence of stroke compared to other risk factors but all of these risk factors can be eliminated with lifestyle modification.