Abstract: Background and Objective: The pattern and severity of HIV/AIDS cases in Indonesia and Merauke Regency of Papua Province are on the increase. There is a limited study on the epidemiologic analysis of HIV/AIDS cases in Merauke Regency. This study aimed to identify trends in HIV/AIDS epidemics in Merauke Regency. Materials and Methods: Data were obtained from Info AIDS from 1992-January, 2017 under Disease Control and Environmental Health of Merauke Regency. The univariate, correlation and polynomial regression models and SPSS 19 were used as statistical tools for analyzing data. Results: During the study, 1,063 people tested positive for HIV in Merauke Regency, 902 people had AIDS and 537 died due to AIDS-related causes. The association between reported HIV infection cases and AIDS-related deaths yielded a Pearson correlation of 0.8053 (p<0.0001), however, there was no correlation between reported cases (HIV infection cases and AIDS cases and between AIDS cases and AIDS-related deaths). The values of a variation curve of the 5th-degree polynomials were 40.86, 60.17 and 58.90% for reported HIV infection cases, AIDS cases and AIDS-related deaths, respectively. Conclusion: It was concluded that data obtained in this study can be used as a basis for making policies and programs to reduce the spread of HIV and AIDS.