Abstract: The malaria cases were increasing in Mamuju district. Several factors influence of the malaria prevention specifically socioeconomic and access to health services. The objectives of the study were to find out socioeconomic determinants, access to health services and behaviour towards prevention of malaria in Mamuju district, West Sulawesi. The design study was cross sectional. The population of this study was the residence in Mamuju District, number sample 739 respondents taken by random sampling and data analysis by using Chi-square and logistic regression in α 5%. Results of the study reveal that 51% of respondents have done malaria control in the Mamuju District. Socioeconomic factors like education (p = 0.000), income (p = 0.004), knowledge (p = 0.000) and attitude (p = 0.000) were significant to prevent malaria. Variables that are not related were employed (p = 0.060) and access to health services (p = 0.223). Logistic regression analysis showed that behavior; knowledge and attitude most impact for prevention of malaria in the district Mamuju. This research recommended the dissemination of health information about malaria prevention to the public through various media both of print and written media also counseling.