Abstract: Background and Objective: Coronary Artery Disease (CAD) is the major leading cause of death worldwide according to WHO 2011. The aim of drug utilization research in Coronary artery disease was to facilitate the rational use of drugs in a specialized group of populations. The main objective of the study was to analyze the current trend of prescribing patterns of the drugs used in the management of Acute Coronary Syndrome at study site. Materials and Methods: The prospective observational study was conducted for a period of 6 months in the Department of Medicine from Shri B. M. Patil Medical College, Hospital and Research Center. A total of 120 patients were selected for the study. Patient case files (including patient’s specific information, drug therapy and laboratory investigations) were used to extract the necessary data. The percentages of data were calculated with the help of regular Microsoft excel 2007 sheet and the Sample size was calculated using the formula. Risk factors contributing to the development of Acute Coronary Syndrome were analyzed and various clinical pharmacy services were provided as a part of the study. Results: Out of the 120 patients enrolled in the study majority were male (81) and were found in the age group of 60-69 years. Smoking constituted the dominant risk factor followed by hypertension. Drug Related Problems (DRPs) found to be equally prevalent among all the age groups and were equally distributed among both the genders. Cessation of drug 28 (23%) and change in dose 17 (14%) were the interventions most frequently provided. The treatment received by the patients was in partial accordance with the ACC/AHA guidelines which was used as a comparative standard for the study. The study also unveiled the scope for the modification of this partial status to whole with the active participation of clinical pharmacists at the bed side. Drug utilization pattern among ACS patients were examined with the help of WHO prescribing indicators. Conclusion: The results were not optimal in accordance with the standard values of WHO prescribing indicators which suggest the necessity of modifying the hospital drug formulary and also to create awareness among physicians about rational drug use. On the whole, this study highlights the need of appropriate and timely interventions by the clinical pharmacist for the improvement of drug use, the patient’s quality of life and to minimize DRP’s.