Abstract: Self micro-emulsifying drug delivery systems (SMEDDS) are vital tool for enhancement of oral bioavailability of hydrophobic drugs. These systems are currently of interest to the researchers because of their significant capability to act as drug delivery vehicles by incorporating a extensive range of drug molecules. The present communication embodies approaches in the design of lipid based formulation, evaluation processes, mechanism involved there in, updated with latest findings from literature reports and patents. Also, this comprehensive review offers an explicit discussion on vital possibilities of the SMEDDS in bioavailability improvement of various drugs. A pseudo ternary phase diagram is used for identifying the micro-emulsification region. Thus, this current article provides an updated compilation of extensive information and result on all the unexplored areas of the self micro emulsifying drug delivery systems, thus encouraging the researchers to accelerate their research work in this direction for the development and enhancement of dissolution profile of hydrophobic drugs and pay a novel approach to pharmaceutical research.