Abstract: In developing countries, typhoid fever has a substantial negative socioeconomic impact. Highly invasive organism, Salmonella typhi is the causative agent for this enteric fever. The virulence of Salmonella is associated with the presence of a capsular polysaccharide, Vi antigen. The Vi polysaccharide biosynthesis protein, tviC, of Salmonella typhi whose three dimensional structure was not elucidated till date and its sequence was retrieved from KEGG database. Homology modeling was performed using Swiss model and the resultant structure was verified using WHATCHECK tool. Docking studies were done on the modeled structure with plant derived inhibitors such as allicin, apigenin, caffeic acid, curcumin, eugenol, piperin and luteolin. The hydrogen bond interactions between the protein and ligand were visualized by PYMOL software. Docking studies revealed the e-value for eugenol (-329) is better than the other selected ligands.