Abstract: The major functions of the liver can be detrimentally altered by liver injury resulting from acute or chronic exposure to toxicants. Dyslipidemia is often found in such toxicity resulting from chemical damage. Normalisation of atherogenic indices by Chromolaena odorata (C. odorata) in carbon tetrachloride-induced liver toxicity was evaluated in 30 male rabbits divided into 5 groups of 6 animals each. Normal Control (NC) received food and water only. Carbon tetrachloride intoxicated control (CCl4) received a single dose of CCl4 (0.2 mL kgbw-1 in liquid paraffin 1:1). C. odorata test animals (ETECO TEST) received a single dose of CCl4 + ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1 morning and night, for 6 days. C. odorata control animals (ETECO CTRL) received ethanol extract of C. odorata at 400 mg/kg/day in two divided doses of 200 mg kg-1. Group five (Sylimarin) received sylimarin 50 mg/kgbw prior to CCl4 intoxication. Carbon tetrachloride-induced toxicity resulted in liver injury which was seen from the significant (p<0.05) elevation of the activities of serum Aspartate Aminotransferase (AST), Alanine aminotransferase (ALT), Lactate Dehydrogenase (LDH) and gamma-Glutamyl Transferase (γ-GT), significantly decreased protein and albumin and significantly increased total bilirubin concentrations; altered lipid and lipoprotein phenotypes in favour of increased atherogenic indices. Pre-treatment with C. odorata extract prevented these biochemical alterations and normalized the lipoprotein phenotypes. C. odorata may be useful not only as a hepatoprotective agent, but also in the reduction and/or prevention of adverse cardiovascular events.