Abstract: The adolescents suffering from Poly Cystic Ovarian Syndrome (PCOS) are concerned about weight gain, menstrual irregularities and cutaneous manifestation (hirsutism, acne and alopecia). The present study aimed to investigate the prevalence of cutaneous manifestations in 14-18 year old female high school students based on PCOS. This descriptive-analytical study was conducted on 3200 female students between 14 and 18 years old in 2009. The intensity of hirsutism was determined using modified Ferriman-Gallwey scale. In addition, the intensity of acne was classified based on the classification consensus conference on acne. Finally, alopecia was assessed using Ludwig’s scale based on scalp and forehead line hair density. Experiments (prolactin, TSH, DHEAS, total testosterone and free testosterone), hyperandrogenism clinical features and sonography were performed. Then, the data were analyzed using Chi-square test. The prevalence of hirsutism, acne and alopecia were 3.2, 5 and 4.2%, respectively. The results revealed no significant relationship between the mean of androgens as well as suffering from PCOS and hirsutism and alopecia (p>0.05). However, a significant relationship was found between menstrual irregularities and hirsutism (p<0.001). Also, a significant relationship was observed between the testosterone level and PCOS (p<0.001). Among the cutaneous manifestations, severe acne and androgen level were significantly related to PCOS. Considering the consequences of acne in the girls’ lives, hormonal screening and sonography are recommended to be performed in the girls with average acne and normal menstrual cycles, as well.