Abstract: Nowadays, reusing drainage water in Egypt represents a major potential water resource for expanding more cultivated area. This study was conducted during 2011 and 2012 seasons to test the possibility of reusing the agricultural drainage water for irrigating of Taimour mango transplants. In addition, to examine the effect of this water on some vegetative growth and root characters, total carbohydrate percentage in the leaves, plant pigments and uptake of N, P, K, Na ad Cl by plants. Transplants were irrigated with both drainage water and Nile water alone and also with different proportions from each (75:25, 50:50 and 25:75). The obtained data reveal that irrigation with drainage water alone or mixed with Nile water at a ratio of 25% badly affected all the investigated parameters of transplants. A positive relation between the proportion of drainage water and the uptake of Na and Cl. Irrigation using drainage water mixed with river Nile at a ratio of 50-75 was apparently no depressive effect on all of the considered aspects of the transplants. From the economical standpoint, drainage water may be mixed in equal parts (50: 50%) with river Nile for irrigate Taimour mango transplants growing on sandy soil. For more safety, irrigation with Nile water may be applied for leaching soil and preventing salt accumulate every four mixed water irrigation.