Abstract: Rice is the staple food for more than half of the world’s population. Arsenic (As) contaminated irrigation water (groundwater) is a threat to irrigated rice cultivation. A pot study was conducted to mitigate Arsenic (As) problem in rice by two water managements (aerobic and anaerobic) practices. In this study two rates of As (0 and 40 mg kg-1) were applied as; aerobic As0, anaerobic As0, aerobic As40 and anaerobic As40 and other two treatments were kept as aerobic As40a (before flowering anaerobic and after flowering aerobic) and anaerobic As40b (before flowering aerobic and after flowering anaerobic). A rice variety, BRRI dhan28, was grown. Application of 40 mg kg-1 As significantly affected plant growth in anaerobic condition. The higher seedling survibility, filled grain and yield were in aerobic condition. The tissue analysis showed that plant grown in aerobic condition contained less contents of As in root (20%), straw (97%) and grain (61%). Thus, aerobic rice cultivation can be a sustainable technology to mitigate arsenic problem in rice at arsenic contaminated soil.