Abstract: This study was convened because of low levels of tomato produced in soils of Tanzania with poor fertility status. It compared effects of poultry manure and NPK (23:10:5) fertilizer to the performance of tomato (Lycopersicon esculentum Mill). Poultry manure was applied at 2, 4 and 8 t ha-1 and NPK fertilizer at 20, 40 and 80 kg ha-1. Results showed that the highest number of leaves (70) and shoot length (93 cm) were recorded at 8 t ha-1 and lowest (46 and 57 cm, respectively) at 2 t ha-1 of poultry manure. These variables were far small (18 and 55 cm, respectively) for absolute control. In addition, 40 kg NPK ha-1 recorded the highest shoot length (91 cm) and 20 kg NPK ha-1 lowest (60 cm). Many tomato fruits (31) were produced at 8 t ha-1 poultry manure compared with 22 in 40 kg NPK ha-1 and differed significantly (p<0.001) with absolute control (5) and among treatments. The smallest (823 g) and highest (2338 g) weights of fruits recorded per plant at 2 and 8 t ha-1 poultry manure, respectively, differed significantly (p<0.01) among treatments and absolute control (341 g). The smallest (676 g) and highest (1668 g) weights recorded at 20 and 40 kg NPK ha-1, respectively, also differed significantly (p<0.01). It was concluded that poultry manure at 8 t ha-1 and NPK (23:10:5) fertilizer at 40 kg ha-1 are sufficient for tomato plants but the former outweighs the latter.