Abstract: Drought is a pervasive problem throughout most of the world's cultivated regions and it has been recognized as the single most important limitation to productivity. The present study was carried out to evaluate two maize inbred lines for their drought stress tolerance in the field. These two inbred lines were chosen as drought tolerant (Sd-63) and drought sensitive (Gm-18) for hybridization to obtain the F1 generation and then selfed to obtain the F2 generation. These two maize inbred lines and their F1 and bulks of the two extreme F2 plant groups (the most tolerant F2 group and the most sensitive F2 group) were tested against six RAPD (Random Amplified Polymorphic DNA) primers to determine some molecular markers for drought tolerance in maize. This analysis revealed that, four RAPD primers (A01, A05, A06 and B08) out of the six developed molecular markers for drought tolerance in maize. These RAPD markers could be considered as reliable molecular markers associated with drought tolerance in maize that can be utilized during breeding programs via marker-assisted selection.