Abstract: Background: Peripheral inflammatory markers are elevated in obese patients. Controlling inflammation and reducing inflammatory markers by diet and losing weight may help to slow down the cognitive dysfunction accompanying the aging process. Objective: We examined whether high sensitivity C-reactive protein hs.CRP level in midlife is correlated to cognition and subsequent cognitive functions improvement with diet modification and weight loss. Methodology: Ninety one obese volunteer women participated in this study which lasted for 8 weeks. The patients were to follow balanced low caloric diet (900-1000 cal day–1) with 8 servings of fresh vegetables and fruits. The patients mean age was 48.23±5.32 years and had a mean Body Mass Index (BMI) of 36.75±2.89 kg m–2. Evaluations were made at base line and 8 weeks later. This included: Quantitative determination of hs.CRP, cognitive and mental evaluation (MMSE), clinical examination and anthropometric measurements. Fasting blood glucose (FBG), serum lipid profile and C-peptide were assessed and insulin resistance was calculated. Results: After intervention, improvement in cognitive functions were recorded with decrease in hs.CRP serum levels. Significant inverse correlation was found between cognitive functions and hs.CRP levels, insulin resistance, waist circumference and BMI. Conclusion: Serum hs.CRP level may be used as a marker for cognitive functions impairment in obese middle age females and could serve as a base for intervention.