Abstract: The aim of the study was to explore the effects of these intonations on the reflector nerve and muscle terminals of guinea pigs using electron microscopic approaches. Spazmatic shrinking of myocyte myofibrils together with degenerative changes in myocytes and nerve terminals occur with the application of strained intonations. Transmission function is also damaged related with this situation. Clear relaxative extensions in myocyte myofibrils and decrease in activity of nerve terminals were determined with the application of more extensive intonations.