Abstract: Protective effect of fresh apple skin extract on Human Umbilical Vein Endothelial Cells (HUVEC) against glycated protein (GFBS)-iron chelate (FeCl3) induced toxicity was studied. HUVEC incubated in glycated protein either alone or combined with iron chelate showed a significant (p<0.001) elevation of lipid peroxidation (LPO) accompanied by depletion of superoxide dismutase (SOD), catalase, Glutathione Peroxidase (GPx) and Glutathione Reductase (GR). Treatment of HUVEC with apple extractat a concentration of 50 mg showed a significantly decreased level of LPO with concominant increase of antioxidant levels to near normal. Morphological changes of HUVEC were compared with respective control. Our finding indicate that apple skin extract has protective effect against glycated protein-iron chelate induced toxicity, which suggests that apple extractcould exert a beneficial effect on preventing diabetic angiopathies.