Abstract: Background and Objective: The lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrichidae) is a very harmful insect pests to cereals grain including wheat. Three oils tested on this pests they are thyme, frankincense and turmeric under laboratory and store conditions. Materials and Methods: The tested nano-oils were experimented at tested concentration (0.5%) for their insecticidal activities against the 3rd instar larvae of tested insects. After 7 days of exposure, accumulative mortality percentages were calculated in the treated and untreated control. Also, the tested nano-oils were sprayed to the foam granules and were mixed with wheat (2 g foam/100 g wheat) for testing the oviposition inhibitory effects of tested oils. The experiment was designed to test the persistent effect of tested oils against tested species on foam as surface protectant after 90 day intervals. Results: Results showed that the accumulative mortality percentage was gradually increased after increasing the period of exposure to foam treated with the thyme, frankincense and turmeric tested. Nano-oils showed a highest accumulative mortality (99.0, 89, 87%) when treated with thyme, frankincense and turmeric, respectively. The reduction of the eggs laid per female was scored 99.3% eggs/female after treatments with nano-thyme. Under store conditions the percentage of infestations was significantly decreased to 2, 7 and 10% after treating the stocks sacs with thyme, frankincense and turmeric, respectively as compared to 99% in the stock sacs control (untreated). Conclusion: The three natural oils and its nano-compositions decreased the infestations numbers of R. dominica under laboratory and store conditions.