Abstract: Background and Objective: Several studies have empirically demonstrated the insecticidal activities of the root powder and/or extract of Chromolaena odorata (L.) King and Robinson (Asteraceae) against several insect pests, however studies on the insecticidal activity of the root powder of the plant against bedbug species are scarce. This study examined the insecticidal activity of the root powder of C. odorata against the tropical bedbug, Cimex hemipterus (F.) (Hemiptera: Cimicidae). Materials and Methods: Five unsexed adult C. hemipterus were exposed to different concentrations (0.0, 1.0, 1.5 and 2.0 g) of C. odorata root powder in the laboratory after which percentage mortality was monitored every 24 h for a period of 168 h (= 7 days). Results: Percentage bedbug mortality was observed to be independent of the duration of exposure to, but dependent on the concentrations of C. odorata root powder used. Following a 168 h exposure period, the highest concentration (2.0 g) of C. odorata root powder, accounted for the highest percentage mortality (80%) against C. hemipterus. Conclusion: This study is the first to examine the insecticidal activity of the root powder of C. odorata against C. hemipterus and it further suggests its usage in the management and control of the pest in the tropics