Abstract: Background and Objective: The effects of root bark powder of Cleistopholis patens Benth on toxicological and histopathological properties of albino rats was investigated using standard method. Materials and Methods: A total of 30 Wistar rats were grouped into 6 (A-F) of 5 rats each. The rats in group (A-E) received 2-10% of the powder while the rats in group F were given only the animal feeds, this group served as the control. Results: The results revealed that the alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total protein, urea and creatinine levels in the control group were not significantly different from the experimental animals. Conclusion: The results obtained in this research work suggested that C. patens root bark powder can be consumed by human being along the protected cowpea seeds since it caused no toxicity to the liver and kidney at the highest dose of 10% to albino rats.