Abstract: Background and Objectives: Hypertension is characterized by an increase in systolic and or diastolic blood pressure. Arterial stiffness is an independent cardiovascular risk factor in hypertensive patients. Increasing arterial stiffness correlates with hypertension progression. This study aimed to determine anti-hypertensive activity and reducing arterial stiffness, combination of Centella asiatica and Curcuma longa, in 25% fructose-induced hypertensive animal models in drinking water and high-fat diet. Materials and Methods: This study was conducted on male Wistar rats with 3 methods: Diuretic test, anti-hypertensive test and arterial stiffness test by non-invasive method. Two doses combination of Centella asiatica and Curcuma longa were at 3.6 and 1.8 g kg–1 in juice preparation, compared to furosemide (diuretic test), captopril (anti-hypertensive test). Parameters measured were urine volume, systolic and diastolic blood pressure and Pulse Wave Velocity (PWV). Results: Combination of Centella asiatica and Curcuma longa in juice preparation, increased urine output (diuretic), decreased systolic and diastolic blood pressure and improved arterial stiffness (p<0.05) compared to the control group. Conclusion: Combination of Centella asiatica and Curcuma longa in juice preparation has anti-hypertensive activity and improved arterial stiffness.