Abstract: The study was designed to investigate the pharmacognostic parameters of the aerial parts as well as antimicrobial and antioxidant activities of methanol extract of Pulicaria somalensis O. Hoffm (MEPS). These studies were carried with a view to justify the future use of this plant. This study deals with the morphological, microscopical studies of leaf, aerial part of P. somalensis, along with the physicochemical and preliminary phytochemical analyses that were also studied. The antibacterial activities were tested against both Gram-positive and Gram-negative bacteria while antifungal activities were tested against Aspergillus niger and Candida albicans using the agar disc diffusion method. The zone of inhibition was compared with standard (Ampicillin). The study of in vitro antioxidant was performed by using DPPH and FRAP assays. The results of the present morphological study correlated with earlier reports. The microscopical and physicochemical finding explores the useful identification character for authentication of this plant. The preliminary phytochemical study showed the presence of phenol, tannins and flavonoids types of active drugs. The marked antibacterial, antifungal and antioxidant were observed, which may be due to the presence of active constituents present in MEPS. The outcome of the present findings suggested that the plant may be a good source of antibacterial and antioxidant. The present finding concluded the in vitro activities, so it needs to be explored more in vivo evaluation before adding it into the world of medicinal plants.