Abstract: Extracts of roots and leaves of Centella asiatica (Linnaeus) Urban were used to evaluate their antimalarial effect against Plasmodium berghei in vivo in a typical 4 day test. Alcohol soluble extracts were administered orally in experimental mice along with placebo controls. On day 4 parasitaemia in control group of mice was 21.54±1.75% while in mice treated with roots and leaves extracts showed 5.73±1.14% and 11.89±1.25% infection, respectively.