Abstract: In silico docking techniques are being at this instant have great investigation utensil for molecular analysis. The principle binding situate of this protein would be BRCT considered for expression and regulation of BRCA1. The BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. The present study focus on docking and toxicity scrutiny of well descriptive peptides and the results suggested that Z Dock score suggested higher score with peptide p-ACC1 and ATRIP peptide and the toxicity examination were carried out using ToxinPred on line tool suggested that ATRIP peptide has lesser toxicity controversy with peptide p-ACC1 has greater toxicity. Further concluded ATRIP and p-ACC1 suggested for further studies.