Abstract: Beta thalassemia is an inherited autosomal recessive blood disease. In beta thalassemia and hemoglobinopathies, the genetic defect which could be either mutations or deletion results in reduced rate of synthesis or no synthesis of one of the globin chains that make up haemoglobin. Reduced synthesis or no synthesis of one of the globin chains can cause the formation of abnormal haemoglobin molecules, thus causing anemia, the characteristic presenting symptom of the thalassemia. The present study was undertaken with objective to study the occurrence and socio-demographic profile of hemoglobinopathies cases of Chittagong city. It may provide accurate data of population frequency that are necessary for the planning of control thalassemia in the highly populated eastern part of Bangladesh. This is a hospital record based prospected study that was carried out in two different General hospitals in Chittagong town where both hospitalized as well as out patients were included. The study was carried out from November 2011 to April 2012. A total of 485 suspected patients who were admitted in the hospitals were included in this study. Data was collected and then studied and analyzed properly. Analysis was done by employing Statistical Package for Social Science (SPSS Version 10.0) software package. Here the difference of male and female patients was found statistically insignificant (p>0.05). It was observed that, the onset of hemoglobinopathies was significantly high at neonatal to childhood period <1-10 years and the percentage was 51.70% (p<0.05). Here, the prevalence of HBE β Thalassemia patients (38.65%) was found the highest in percentage.