Abstract: In the present study, Bridelia retusa bark was screened for their hypoglycemic potential on normal, oral glucose tolerance study and alloxan induced rats. Albino rats were divided into groups (n = 6) received different treatments consisting of control, methanolic, pet-ether and n-butanol extracts (at a dose of 200 and 400 mg kg-1) and standard drug Glibenclamide (5 mg kg-1 p.o.). Estimation of blood glucose level was done by GOD/POD method. Results indicated that B. retusa extracts does not affect blood glucose level on normal rats but in Alloxan induced diabetic rats n-butanol extract showed significant (p<0.001) fall of blood sugar level. However, the effect of drug was less than standard. Phytochemical analysis has revealed the presence of steroids, triterpenoids, tannins and flavonoids as major constituents.