Abstract: Background and Objective: Acute Renal Failure or disease (ARF) is a complicated disorder that causes a fast reduction in kidney function and anemia is a common feature of this disease. This study aimed to evaluate the anemia situation in patients with acute renal failure among men and women. Materials and Methods: This case study was conducted on 56 patients with acute renal failure attending DEE Medical Center, Buruku, Jos, Plateau State Nigeria, from January-September, 2019. Initially, two separate blood samples were taken from each patient, 2 mL uncoagulated sample harvest for biochemical assay and EDTA anticoagulated whole blood sample for hematocrit value. Serum was used to determine the level of urea, creatinine and hematocrit value was done with EDTA anticoagulated samples by hematocrit centrifuge. The values obtained in urea and creatinine were divided into three groups: low, moderate and high, data obtained were analyzed by SPSS software. Results: Generally, the study revealed the anemic condition of all the acute renal disease patients irrespective of gender (p<0.05). However, it was discovered that the mean hematocrit value of females (22.2+3.3) was higher than of males (19.8+2.5). Conclusion: It was discovered that the severity of anemia in acute renal disease in men was as a result of the effect of the disease on testosterone level synthesized in the kidney, therefore, it is recommended that testosterone can be used as alternative or complementary for erythropoietin to boost up hematocrit value in severely anemic patients and management of acute renal failure in men.