Abstract: In previous studies, using a bioassay-guided fractionation procedure; five fractions (E1F1, E2F2, E3F3, E4F4 and E5F5) from powdered Borassus aethiopum male inflorescences were extracted. Among these, the dichloromethane methanol extract E2F2 was found to exert significant anti-inflammatory and antipyretic activities and pro apoptotic effect. It seemed important to pursue the investigations to understand the mechanism of the anti-inflammatory activity. The anti-inflammatory activity was studied, C Reactive Protein (CRP) level in mice blood was immunoturbidimetry after inflammation induction and antioxidant activity was studied using 1,1 diphenyl picrylhydrazyl (DPPH). Phytochemical screening was carried out according to the methodology for chemical analysis for vegetable drugs. Among 3 fractions (I1; I2, I3) of E2F2, I1 was the most active with a percentage of inhibition (PI) of 80%. This anti-inflammatory activity was twice high than indometacin (PI = 40%). The I1 fraction cause significant decline of concentration of CRP compared with indometacin. The radical scavenging activities of I1 were approximately 4 times lower than ascorbic acid. Phytochemical analyses of Borassus aethiopum extracts revealed the presence of terpenoids, steroids and saponins which all have been shown to be potent anti-inflammatory and antioxidants. The present study confirmed the anti-inflammatory and antioxidant potential of Borassus aethiopum extracts with results comparable with those of standard compounds such as indometacin. Further studies are needed to isolate, purify and identify the chemical structure of the compounds responsible for anti-inflammatory and antioxidant activity.