Abstract: The aim of the study was to evaluate and compare oxidase and ferroxidase ceruloplasmin activities (U L-1) and their specific activities (U g-1) in sera of celiac patients with different histopathological severity. This study included 75 celiac patients with different mean age (18.68±11.13) year, who had positive screen for celiac antibodies and who had gastrointestinal symptoms. In order to simplify the comparison with the healthy control group, celiac patients were divided into two groups according to their histopathological severity: Severe (marsh III a, b, c) and less severe (marsh 0,I). All these patients have been evaluating for S.CP. ferroxidase and S.CP. oxidase activities as well as its specific activities. Furthermore, the concentrations of total protein, albumin, copper and iron, were measured too. Non-significant increase (p>0.05) in serum ferroxidase activity of ceruloplasmin was found in all above mentioned patients groups in comparison to that of the control group, while its specific activity showed a significant increase for more severe mucosal histopathological damage (marsh III a, b, c) patients and (p>0.05) for less severe mucosal histopathological damage (marsh 0,I) patients in comparison to that of control group. As far as serum oxidase ceruloplasmin activities is concerned, a significant increase (p<0.05) was observed in all patients groups, while its specific activity showed non-significant increase (p>0.05) in sera of more severe mucosal histopathological damage (marsh III a, b, c) patients and a significant increase (p<0.05) for less severe mucosal histopathological damage (marsh 0,I) patients. Among the patients groups, serum copper levels showed non-significant increased (p = 0.1) and serum iron level was found to decrease significantly in patients with more severe mucosal histopathological damage (marsh III a, b, c) in comparison to that of control group. Meanwhile the mean values of patients total protein and their albumin were found to show non-significant increase (p>0.05) in comparison to that of the control groups.