Abstract: Methicillin resistant Staphylococcus aureus (Micrococcus aureus) or better known as MRSA is well known. The organism has become a common name in most of the nosocomial infections. This organism is also known to be resistant to related antibiotics like cloxacillin and amoxicillin. The reverse is also true that those strains resistant to cloxacillin and amoxicillin are also resistant to methicillin. It has been hypothecated that this organism carries an extra chromosomal DNA which is responsible for the methicillin resistant. This investigation attempts to find whether such antibiotic resistance is also prevalent amongst related species of Micrococcus. Using the above mentioned reports, experiments were designed to find out in vitro resistance of Micrococcus sciuri strain JSG-1 which was isolated in our lab from a nosocomial infection case, to cloxacillin and amoxicillin. It was found that this strain of Micrococcus sciuri showed resistance to 5000 ppm of both cloxacillin and amoxicillin individually. The importance of this finding is that hospitals must step up their sanitation practices to minimize nosocomial infections by such resistant strains.