Abstract: Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine disorders affecting 4-12% of women worldwide; contributing to long term complications associated with high oxidative stress and chronic low grade inflammation, demanding the understanding of diverse contributing factors for better management of this multifactorial condition. Haptoglobin polymorphic forms, an acute phase protein vary with respect to antioxidant activity, angiogenesis and immunomodulatory function. In order to analyze the distribution of various phenotypes of Hp in relation to PCOS, the present study was carried out. A total of 193 patients and 187 healthy age matched, ultrasound scanned controls were included in the present study. Blood samples were obtained for Hp phenotyping by PAGE. The percentage of Hp1-1, Hp1-2 and Hp2-2 phenotypes were 2.07, 33.67, 64.24 and 0.53, 49.19 and 50.26 in patients and controls, respectively. Sizeable increase in the frequency of Hp2-2 (15.5%) and decrease in the frequency of Hp 1-2 in the patients compared to controls suggests heterozygous condition to be significantly protective over the homozygotes in PCOS. The present investigation may be the first one from South Indian population, dealing with distribution of haptoglobin phenotypes in PCOS patients and its relevance with respect to anthropometric measures and serum malondialdehyde levels.