Abstract: Background and Objective: Elevation of the serum hepatic enzymes increased the length of hospital stays in burn injury patients. This study was aimed to investigate the effect of the perennial herb, A. keiskei on levels of serum hepatic enzymes, renal function and wound size in scalded rats. Materials and Methods: Scald wound rat model was created by hot water on the dorsal surface. Rats in control groups were given a placebo, but the rats in treatment group were given A. keiskei extract (300 mg kg–1 b.wt.) after the burn treatment for 14 days. Blood serum was analyzed for ALT, AST, ALP test on the 2nd, 8th and 14th day. The burnt wound size was measured on the 1st, 5th, 8th, 12th, 15th and 18th day. For statistical analysis, the Wilcoxon signed rank test to analyze the levels of ALT, AST, ALP, urea and creatinine in serum. The wound sizes between the groups were analyzed with Mann Whitney U Test. Results: In the control group, the levels of ALT and AST showed no statistical differences. However, in the treatment group, the levels of ALT on 8th and 14th day and levels of AST on 8th day were decreased. The levels of ALP in the control group were increased on 8th and 14th day, in the treatment group, the levels of ALP on the 8th day decreased significantly. Levels of creatine and urea serum in the treatment group showed no significant difference. Statistic differences of wound sizes, between control and treatment groups were significant on 15th and 18th day. Conclusion: Angelica keiskei extract decreased the levels of serum ALT, AST, ALP and scald wound size in scalded rats.