Abstract: Acrylamide is well known to be a Central Nervous System (CNS) toxicant. In this study the effects of dietary acrylamide formed in fried rice on the hematological values, thyroid hormones levels, liver, kidney functions and lipids profile in serum have been investigated. Male Albino rats were divided to three groups, G1 (control), G2 (fed on fried rice) and G3 (fed on fried rice+grape leave). Histopathological examinations of liver, kidney, brain, pancreases, lymph nodes and thyroid gland were carried out. Our results indicated that acrylamide administration in fried rice (G2) significantly decreased daily body weight gain, HB, RBCs, WBCs, HCT, platelet, T3, T4 and HDL cholesterol. However, TSH, liver, kidney function and lipid profile were significantly increased, while, a decreasing in these parameters has been noted in G3, which received grape leave in combination with fried rice. Besides, T3 and T4 analysis have been increased in G3. It can be stated that acrylamide effects on the thyroid hormones, which affects other body hormones and appeared on experimental rats. It was noted that grape leaves reduced the effect of acrylamide and led to improved physiology.