Abstract: Dengue fever is one of the most threatening epidemics of this era and there is no targeted vaccine and therapy. The present study was designed to elucidate the natural compounds as therapeutic targets for dengue virus. In this study, it is proposed that target approach for dengue drug discovery based on natural ligands obtained from plant extract of C. papaya. Nonstructural proteins were retrieved from the protein data bank and natural compounds were drawn using drawing tool, before docking. All of them were subjected to drug and absorption distribution metabolism toxicity analysis which shows satisfying results which leads to docking studies. Series of 8 compounds have been screened and docked for binding energy prediction and on the basis of lowest binding energy, the potential ligands like 2-Methoxy-4-vinylphenol, 9-Octadecyne and 9, 12, 15-Octadecatrienoic acid, (Z, Z, Z) are recommended for further studies.