Abstract: This report describes QSAR and SAR studies on the Inhibition of Reveres Transcriptase (RT) by 79 TIBO (Tetrahydoimidazobenzodizepin-2-one) derivatives using both classical and unconventional physicochemical properties and quantum molecular descriptors along with indicator parameters. The application of a multiple linear regression analysis indicated that a combination of classical physicochemical descriptors and the indicator parameters yielded a s tatistically significant model for the activity, log 1/C (50% of inhibition concentration of TIBO derivatives for RTs). The final selection of a potential TIBO compound for the inhibition of Reveres Transcriptase is made by quantum molecular modeling. We have found that, among the a number of Quantum and modeling parameters, the electron density on the 9th atom correlated best with the activity.