Abstract: The effect of solar, sun and oven drying on the nutrients and non-nutrients composition of leaves of Gynandropsis gynandra was determined. Ash content of sun (3.14±0.09%), solar (3.16±0.03%) and oven (3.30±0.08%) dried samples were significantly (p<0.05) increased compared to fresh samples. All the drying methods were found to significantly (p<0.05) lower moisture, carbohydrates and protein. However, crude fibre content was significantly (p<0.05) increased with drying method. Drying method, with exception of oven drying, did not significantly (p>0.05) lower lipid content. Significant (p<0.05) increases of mineral elements upon drying with exception of sodium were observed. Alkaloids, tannins, saponins, saponins glycosides, flavonoids and volatile oils were detected in fresh and dried samples. These phytochemicals detected were found to decrease upon drying to trace amounts. Solar and oven drying were found to significantly reduce acid value from 3.91±0.31 to 1.66±0.06 and 2.69±0.33%, respectively. Solar drying may be the preferred method of drying the leaves of Gynandropsis gynandra as it is faster, more hygienic and preserves the nutrients better.