Abstract: Background: Reproductive communication in ungulates is thought to be accomplished by means of odors associated with many cuteneous glands; preorbital, interdigital and tarsal glands. The preorbital gland varies in its morphology according to animal species. Objective: The purpose of the current study was to describe the histomorphology, histochemical structure and morphometric analysis of the preorbital gland of male and female adult Egyptian native breeds of sheep in order to determine its secretory function. Methodology: Forty adult and apparently healthy sheep were used for gross and histological examination. Some morphometric parameters of the used glands were measured and the obtained data was analyzed by using the independent samples T test, SPSS package 2007, version 15. Results: The results of the current study showed that the gland is pear shaped structure lies in external lacrimal fossa of the lacrimal bone rostral to medial canthus of the eye. Histologically, it composed of outer sebaceous and inner apocrine gland portions under epidermis. The proportion of sebaceous glands is larger than apocrine ones. The former glands are of two types; ordinary and modified type, while the later is composed of apocrine acini lined by simple cuboidal cells. Both two glands reacted positively with Sudan III and Sudan Black but only apocrine acini reacted positively with periodic acid schiff. Conclusion: Based on the macroscopic observation of waxy secretion within the glandular pocket and the microscopic observation of both sebaceous and apocrine glands, it is possible to suggest that the preorbital gland of male and female sheep may produce phermonal secretion used in olfactory communication between animals.